Dysfunction of the immune system and therapeutic options

Interne Veranstaltung (Klinik/Institut)

Module Clinical Reality

Participants will learn how specific inborn errors of immunity affect the immune system and how certain drugs used in the treatment of diseases can cause unintended immune dysfunctions. 

Dysfunction of the immune system and therapeutic options

Participants will first receive a brief overview of the cellular components of the immune system and its strategies and mechanisms used to prevent the spread of pathogens and their products. This will include a summary of the organization of the immune system, its strategies for responding to pathogens, and the major cellular components of innate and adaptive responses. Participants will learn how specific inborn errors of immunity affect the immune system and how certain drugs used in the treatment of diseases can cause unintended immune dysfunctions. 

Case studies highlighting different aspects of immune response in the context of increased susceptibility to infections as well as increased risk of immune dysregulation are presented. Participants will learn about diagnostic approaches including functional assays, flow cytometry and genetics. Treatment options are presented including immunoglobulin therapy, Jak-inhibitors and other immunosuppressive medications.

09.00 – 10.00 Seminar: Brief overview of the cellular components of the immune system and their role in the human body
Michael Schmück-Henneresse

10.00 – 11.00 Seminar and Visit to the Clinic: Dysfunctions of the immune system in cancer patients
Il-Kang Na

11.00 – 11.15 Short Break

11.15 – 12.45 Seminar: Inborn errors of immunity – from symptoms to diagnostics to treatment
Leif Hanitsch

12.45 – 14.00 Lunch Break

14.00 – 15.30 Seminar: Immunology and Transplantation
Nina Babel

Requirements

For optimal comprehension, students should have an entry-level understanding of molecular and cellular biology - with emphasis on gene expression, protein synthesis, signalling molecules and cellular receptors.

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